DNA repair is essential to life and to avoidance of genome instability and cancer. Xeroderma pigmentosum group G (XPG) protein acts in multiple DNA repair pathways, both as an active enzyme and as a scaffold for coordinating with other repair proteins.

DNA lesions are an unavoidable fact of life and it is estimated that, daily, each of our cells is confronted with approximately 104–105 new DNA lesions [1, 2]. These lesions can interfere with essential genome processes, such as transcription and replication,

Resistance of tumor cells to platinum anticancer agents poses a major problem in cancer chemotherapy. One of the mechanisms associated with platinum-based drug resistance is the enhanced capacity of the cell to carry out nucleotide excision repair (NER)