
Estrogen provides neuroprotection against brain edema and …
2014年4月13日 · E2 (33.3 µg/Kg) or oil were administered 30 min after TBI. 1 dose (150 µg/Kg) of each of MPP, PHTPP, and (4 mg/kg) ICI182780 was injected two times, 24 hr apart, before …
Targeting Estrogen Receptor Beta Ameliorates Diminished Ovarian …
2025年2月4日 · After 7 days of DOR induction, the mice were subjected to daily intraperitoneal (i.p.) treatment with PHTPP or vehicle for 14 days (2 mg/kg or 4 mg/kg). Our preliminary …
PHTPP | 99.81%(HPLC) | Estrogen/progestogen Receptor antagonist
PHTPP is an ERβ selective antagonist with 36-fold selective for ER βover ERα. PHTPP is fully effective as an ERβ antagonist while exhibiting no significant agonism on ERα or Erβ [1]. Treating cells with PHTPP reduces bladder cancer (BCa) cell growth and invasion, as well as MCM5 …
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Effects of selective estrogen receptor alpha and beta modulators …
2015年4月18日 · PHTPP was dissolved in corn oil and was administered at a dose of 0 (=VEH; N = 8), 0.4 (N = 8), or 4 mg/kg (N = 8) 60 min before PPI testing. Two additional cohorts of male …
Estrogen receptor (ER)-α, β and progesterone receptor (PR) …
2015年11月1日 · Sixty WKY rats were divided into 10 different groups receiving 17β-estradiol (0.2, 2, 20 and 50 μg/kg), progesterone (4 mg/kg), estrogen receptor (ER) antagonist ICI …
PHTPP | Estrogen Receptor/ERR | TargetMol
PHTPP is a selective ERβ antagonist. PHTPP acts as a selective antagonist for estrogen receptor beta (ERβ), significantly decreasing follicle-stimulating hormone (FSH)-mediated cyclic AMP …
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Effects on tumor growth by a combination of tamoxifen and an …
Combining tamoxifen with PHTPP caused a gradual de- crease of tumor size with increasing concentration of PHTPP ( Figure 6 B), further indicating that PHTPP improves the response to...
Roles of Testosterone and Estradiol in Mediation of Acute ...
2020年9月30日 · We investigated whether sevoflurane alters T and E2 levels and whether they contribute to sevoflurane’s acute adverse effects in postnatal day 5 Sprague-Dawley rats.
Journal of Neurochemistry - Wiley Online Library
2008年9月16日 · PHTPP (4.7 mg/kg, s.c.) or its vehicle (77% DMSO and 23% saline) was given once a day for 3 days together with genistein (3 mg/kg) or its vehicle starting on day 9 of …
p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal ...
2021年12月1日 · Caco-2 cells were treated with TNF-α (10 ng/ml) and therapeutic drugs (including HA, mesalazine and PHTPP) for 24 h. The results showed that oral …
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