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  1. Acetyl-CoA-independent malonyl-CoA biosynthesis - Nature

  2. Targeting pyruvate dehydrogenase kinase 1 overcomes

  3. People also ask
    The natural biosynthesis of malonyl-CoA follows the pyruvate dehydrogenase-acetyl-CoA carboxylase (PDH–ACC) pathway, where pyruvate (C3) undergoes initial decarboxylation to yield acetyl-CoA (C2), followed by carboxylation to produce malonyl-CoA at the expense of ATP.
    Immunohistochemistry (IHC) was conducted to evaluate p-PDHA1 (S293) and PDK1 protein levels in osimertinib-sensitive (OS) and osimertinib-resistant (OR) lung cancer tissues. These tissues were collected during the initial surgery from patients diagnosed with NSCLC.
    PDK1 inhibits the pyruvate dehydrogenase (PDH) complex (PDC), preventing the conversion of pyruvate to acetyl-CoA and leading to its accumulation in the cytoplasm, where it is converted to lactate 15. In contrast, inhibiting PDK activates PDH, which promotes the conversion of pyruvate to acetyl-CoA.
    In contrast, inhibiting PDK activates PDH, which promotes the conversion of pyruvate to acetyl-CoA. This process stimulates mitochondrial respiration, resulting in the generation of excessive reactive oxygen species (ROS), which can impair mitochondrial function and activate apoptotic pathways 15.
  4. Separation-assisted catalysis | Nature Chemical Engineering

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  8. 価格.com - HiKOKI PDH-100J (E) 価格比較

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