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    Lupus, technically known as systemic lupus erythematosus ( SLE ), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe.
    en.wikipedia.org
    The history of SLE can be divided into three periods: classical, neoclassical, and modern. In each period, research and documentation advanced the understanding and diagnosis of SLE, leading to its classification as an autoimmune disease in 1851, and to the various diagnostic options and treatments now available to people with SLE.
    en.wikipedia.org
    Childhood-onset systemic lupus erythematosus generally presents between the ages of 3 and 15 and is four times more common in girls. While the onset and persistence of SLE can show disparities between genders, socioeconomic status also plays a major role.
    en.wikipedia.org
    However, about 50% of people with SLE show rather normal germinal centre. In healthy conditions, apoptotic lymphocytes are removed in germinal centers (GC) by specialized phagocytes, the tingible body macrophages (TBM), which is why no free apoptotic and potential autoantigenic material can be seen.
    en.wikipedia.org
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  5. Lupus - Wikipedia

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