EPDR1 ependymin related 1 - NIH Genetic Testing Registry ...
WEBJan 7, 2024 · ependymin related 1. Gene ID: 54749, updated on 7-Jan-2024. Gene type: protein coding. Also known as: EPDR; UCC1; MERP1; MERP-1. See all available tests in GTR for this gene. Go to complete Gene record for EPDR1. Go to Variation Viewer for EPDR1 variants.
Hypoxia-induced miR-181a-5p up-regulation reduces ...
WEBFeb 2, 2024 · At a mechanistic level, the overexpression of hypoxia-induced miR-181a-5p was observed to inhibit the EPDR1/TRPC1 axis, thereby activating the PI3K/AKT signaling pathway and diminishing the sensitivity to Epirubicin in BC
Ependymin‐related protein 1 levels are elevated in children ...
WEBAug 14, 2023 · EPDR1 is a glycoprotein involved in several physiological and pathological processes, such as maintaining energy homeostasis, thermogenic differentiation, cell adhesion, cellular immunity, and inflammation. 13-15 It contains
Genome-Wide Interaction Study of Dietary Intake and ...
WEBFeb 27, 2024 · The EPDR1 gene encodes a protein similar to ependymins, which play important roles in adhesion of neural cells by intracellular and extracellular mechanisms. 41,42 Ependymins were first observed in fish brains, where they are
New players of the adipose secretome: Therapeutic ...
WEBDec 1, 2023 · EPDR1-KO mice demonstrate a 50% increase in body fat compared to control mice on a chow diet, supporting a role in activating thermogenesis in vivo. Furthermore, EPDR1 deficiency lowers in vivo oxygen consumption rate and physical activity without affecting food intake, strongly indicating that EPDR1 controls energy …
17 variants interaction of Wnt/β-catenin pathway associated ...
WEBMar 27, 2024 · Our results revealed that the paired interactions between EPDR1 rs16879765(C/T) and Gsk3β rs334558 significantly increased stage IV risk of ONFH. And we have also introduced the GMDR approach to...
An update on the secretory functions of brown, white, and ...
WEBDec 5, 2023 · Ependymin-related protein 1 (EPDR1) EPDR1 is a newly identified batokine that is released from brown and white adipocytes and is critical for modulating the homeostatic control of energy balance and thermogenic activity of brown adipocytes during the adipogenesis process [ 153 ].
Major Genetic Risk Factors for Dupuytren's Disease Are ...
WEBJun 14, 2023 · We find that the strongest risk factor inherited from Neandertals is associated with altered splicing of EPDR1 transcripts in 3 tissues relevant for Dupuytren's disease; muscle (P = 1.7 × 10 −23), adipose tissue (P = 1.1 × 10 −11P
HER2 Puzzle Pieces: Non-Coding RNAs as Keys to ...
WEBApr 29, 2024 · In a study conducted by Zhao and colleagues in 2021, they discovered that ependymin-related 1 (EPDR1) was significantly reduced in epithelial ovarian cancer (EOC) tissues. They also found that lower levels of EPDR1 were
HER2 Puzzle Pieces: Non-Coding RNAs as Keys to ...
WEBApr 29, 2024 · In summary, their study provided evidence that EPDR1, regulated by miR-429, acts as a tumor-suppressor gene in EOC by inhibiting the PI3K/AKT pathway. The miR-429/EPDR1 axis could potentially be targeted for personalized treatment of EOC patients in the future [39] .
Skip to content