Discovery of 2-Amide-3-methylester Thiophenes that Target ...
ウェブ2024年4月9日 · Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors
ウェブ2023年10月7日 · Mac1 is an ADP-ribose binding protein and ADP-ribosylhydrolase that promote … Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis.
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ウェブ2023年10月7日 · Mac1 is a critical factor for the replication and/or pathogenesis of all CoVs where it has been tested, including MHV, MERS-CoV, and both SARS-CoV and SARS-CoV-2 [9–11]. Point mutations in the Mac1-binding pocket sensitize CoVs to ART activity and IFN
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient ...
ウェブ2023年6月30日 · ΔMac1 SARS-CoV-2 induced increased levels of interferon (IFN) and IFN-stimulated gene expression in cell culture and mice, indicating that Mac1 blocks IFN responses which may contribute to its attenuation. ΔMac1 infection also led to a stark reduction in inflammatory monocytes and neutrophils.
A single inactivating amino acid change in the SARS-CoV-2 ...
ウェブ2023年8月31日 · Here, we identify a potentially new drug target in SARS-CoV-2. The Mac1 domain is an evolutionarily conserved enzyme in coronaviruses that can remove ADP-ribose post-translational modifications from proteins thereby
Discovery of 2-amide-3-methylester thiophenes that target ...
ウェブ2023年8月28日 · The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed to combat additional SARS-CoV-2 variants or novel CoVs. Here, we describe small molecule inhibitors for SARS-CoV-2 Mac1, …
Study reports new compound that halts replication of COVID ...
ウェブ2024年4月25日 · Research appearing in the Journal of Medicinal Chemistry shows for the first time SARS-CoV-2, the virus responsible for COVID-19, can be inhibited from replicating in living cell cultures using a...
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient ...
ウェブ2023年8月23日 · These results demonstrate that Mac1 only minimally impacts SARS-CoV-2 replication, unlike MHV and MERS-CoV, but is required for SARS-CoV-2 pathogenesis and is a unique antiviral drug target. Keywords: ADP-ribosylation; SARS-CoV-2; coronavirus; interferon; macrodomain.
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ウェブ2024年1月31日 · 各カテゴリーの予定表. [1ページ目] NPO法人 長岡JYFC Official Site NPO法人長岡JYFCは、新潟県長岡市を中心に活動しています。. キッズ、小学生、中学生、高校生を中心としたサッカークラブです。. 県内だけでなく北信越、全国大会出場経 …
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