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See all on WikipediaMetformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is sometimes used as an off-label adjunct to lessen the risk of … See more
Metformin is used to lower the blood glucose in those with type 2 diabetes. It is also used as a second-line agent for infertility in those with polycystic ovary syndrome. See more
The most common adverse effect of metformin is gastrointestinal irritation, including diarrhea, cramps, nausea, vomiting, and … See more
Metformin hydrochloride (1,1-dimethylbiguanide hydrochloride) is freely soluble in water, slightly soluble in ethanol, but almost insoluble in acetone, ether, or chloroform. The pKa … See more
Environmental
Metformin and its major transformation product guanylurea are present in wastewater … See moreMetformin is contraindicated in people with:
• Severe renal impairment (estimated glomerular filtration rate See moreMechanism of action
The molecular mechanism of metformin is not completely understood. Multiple potential … See moreThe biguanide class of antidiabetic medications, which also includes the withdrawn agents phenformin and buformin, … See more
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