「 自己免疫疾患全身性エリテマトーデス(SLE)の発症抑制の ...
WEBMay 22, 2024 · 代表的な全身性自己免疫疾患である全身エリテマトーデス(SLE)の発症を疾患特異的に抑制する仕組みの解明に成功しました。 SLEの副作用のない新規治療法開発への道が開かれました。
Lupus - Wikipedia
WEB4 days ago · Lupus, technically known as systemic lupus erythematosus ( SLE ), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. [1] . Symptoms vary among people and may be …
Disease-modifying therapies in systemic lupus erythematosus ...
WEBMay 22, 2024 · Our 2022 published working definition of disease modification in systemic lupus erythematosus (SLE) was 'minimising disease activity with the fewest treatment-associated toxicities and slowing or preventing organ damage
Full article: FOXP3 gene polymorphisms increase the risk of ...
WEB1 day ago · 2.1. Study sample The case-control study involved 130 SLE patients and 280 healthy controls of northern Chinese Han origin from the Department of Rheumatology and Immunology, the First Affiliated Hospital of Henan ...
Endothelin-1 Correlates with Blood Pressure and Pulse ...
WEBMay 21, 2024 · Systemic Lupus Erythematosus (SLE) is a common autoimmune disease that is classified by IgG complex deposition in end organs including the kidney, heart, and vasculature. SLE disproportionally affects women to men (9:1 ratio), with a high prevalence in African American women. Importantly, patients with an SLE diagnosis have common …
Phase 3 Study to Evaluate Two Regimens of Ianalumab on ...
WEBMay 29, 2024 · The trial will evaluate efficacy, safety and tolerability of two regimens of ianalumab compared to placebo, given as monthly or quarterly subcutaneous (s.c.) injection on top of standard-of-care (SoC) treatment in participants with active systemic lupus erythematosus (SLE). A randomized, double-blind, parallel group, placebo ...
Systemic lupus erythematosus | Radiology Reference Article ...
WEB3 days ago · Systemic lupus erythematosus ( SLE) is a complex autoimmune disease with multisystem involvement. Although abnormalities in almost every aspect of the immune system have been found, the key defect is thought to result from a loss of self-tolerance to autoantigens. Epidemiology.
Human and Murine Toll-like Receptor-Driven Disease in ...
WEBMay 14, 2024 · The pathogenesis of systemic lupus erythematosus (SLE) is linked to the differential roles of toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. TLR7 overexpression or gene duplication, as seen with the Y-linked autoimmune accelerator (<i>Yaa</i>) locus or TLR7 agonist imiquimod, correla ….
Systemic Lupus Erythematosus | Concise Medical Knowledge ...
WEBMay 16, 2024 · Systemic lupus erythematosus (SLE) is a chronic autoimmune, inflammatory condition that causes immune-complex deposition in organs, resulting in systemic manifestations. Women, particularly those of African American
Pediatric Systemic Lupus Erythematosus Differential ...
WEBMay 28, 2024 · Specific conditions to consider in the differential diagnosis of systemic lupus erythematosus (SLE) include the following: Acute anemia. Acute poststreptococcal glomerulonephritis. Chronic...
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