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  1. Baumer
    https://www.baumer.com/medias/__secure__/Baumer_PF20S_EN...
    [PDF]

    Flowmeasurement/FlexFlow PF20S

  2. Nature
    https://www.nature.com/articles/s41467-023-44077-2

    Structures revealing mechanisms of resistance and collateral ...

  3. People also ask
    Why is pf20s an advantageous drug target?
    The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous drug target because its inhibition kills P. falciparum in multiple stages of its life cycle and synergizes with artemisinins.

    Structures revealing mechanisms of resistance and collateral

    nature.com
    Are pf20s-selective inhibitors effective?
    Many efforts have been poured into the development of oral Pf20S-selective inhibitors, with some success. Peptide boronate MPI-13 is optimized to be orally bioavailable but is only modestly selective in targeting Pf20S over human constitutive proteasome and non-selective in being equally potent against human immunoproteasome 17.

    Structures revealing mechanisms of resistance and collateral

    nature.com
    Are pf20s inhibitors bioavailable?
    At present, however, Pf20S inhibitors that spare both human constitutive (c-20S) and immuno-proteasomes (i-20S) are not orally bioavailable.

    Structures revealing mechanisms of resistance and collateral

    nature.com
    Do pf20s inhibitors reduce Art Resistance?
    Thus, Pf20S inhibitors hold the potential to reduce the emergence of resistance to and spread of ART resistance. Many efforts have been poured into the development of oral Pf20S-selective inhibitors, with some success.

    Structures revealing mechanisms of resistance and collateral

    nature.com
    Does the pf20s WT mutation affect 5 inhibitor binding?
    By comparing the structures of the Pf20S WT and Pf20S A117D, we unambiguously found that the A117D mutation not only causes a conformational change in the β5 inhibitor binding pockets, but also a substantial conformational change remotely in the β2 active subunit that enhances the binding affinity of a β2 inhibitor.

    Structures revealing mechanisms of resistance and collateral

    nature.com
    Does a pf20s inhibitor work in a humanized mouse model of malaria?
    The only reported orally bioavailable Pf20S inhibitor with efficacy in a humanized mouse model of malarial infection is a peptide boronate that is only modestly selective for Pf20S over c-20S and has no selectivity over i-20S 17.

    Structures revealing mechanisms of resistance and collateral

    nature.com
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  4. RS Components Ltd
    https://uk.rs-online.com/web/p/flow-sensors/2100726?gb=s

    PF20S-11.010.T528.20.0.0000.0 | Baumer PF20S Series ...

  5. Baumer
    https://www.baumer.com/medias/__secure__/Baumer_PF20S_DE...
    [PDF]

    Durchflussmessung/FlexFlow PF20S

  6. Baumer
    https://www.baumer.com/medias/__secure__/Baumer_PF20S_ES...
    [PDF]

    Velocidaddeflujo/FlexFlow PF20S

  7. acs.org
    https://testpubschina.acs.org/doi/10.1021/acs.jmedchem.9...

    Improvement of Asparagine Ethylenediamines as Anti-malarial ...

  8. rs-online.com
    https://befr.rs-online.com/web/p/flow-sensors/2100724

    PF20S-11.010.T527.20.0.0000.0 | Baumer PF20S Series ...

  9. RCSB PDB
    https://www.rcsb.org/structure/8UD9

    8UD9 - RCSB PDB

  10. Octopart
    https://octopart.com/ja/pf20s-mag-mate-57046049

    PF20S Mag-Mate | Octopart Electronic Components

  11. Mesa
    https://mesamalaria.org/mesa-track/selective-plasmodium...

    Selective Plasmodium proteasome inhibitors as novel multi ...

  13. Images of PF20S

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