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  1. Wiley Online Library
    https://onlinelibrary.wiley.com/doi/10.1111/tpj.16680

    Deciphering PDH1's role in mung bean domestication: a ...

  2. Nature
    https://www.nature.com/articles/s41419-023-05952-4

    PDHA1 hyperacetylation-mediated lactate overproduction ...

  3. People also ask
    Is there a loss of function (LOF) pdh1 allele?
    A few rare loss-of-function (LoF) Pdh1 alleles were identified in G. soja, while only an allele featuring a premature stop codon was selected for pod indehiscence in cultivated soybean and spread to low-precipitation regions with increased frequency.

    Parallel selection of loss‐of‐function alleles of Pdh1 orthologous

    nph.onlinelibrary.wiley.com
    Do orthologous pdh1 genes originate in warm-season legumes?
    We found that orthologous Pdh1 genes specifically originated in warm-season legumes and their LoF alleles were then parallel-selected during the domestication of legume crops.

    Parallel selection of loss‐of‐function alleles of Pdh1 orthologous

    nph.onlinelibrary.wiley.com
    What is pyruvate dehydrogenase (PDH)?
    Therefore, clarifying the pathogenesis of SAKI is critical for clinical treatment. Pyruvate dehydrogenase (PDH) is the first rate-limiting enzyme that catalyzes the oxidative dehydrogenation of pyruvate to acetyl-CoA [ 5 ]. Subunit alpha of PDH (PDHA1) contains the PDH active site [ 6 ]. The activity of PDHA1 can be regulated by acetylation.

    PDHA1 hyperacetylation-mediated lactate overproduction promotes se…

    nature.com
    What is PDHA1 acetylation?
    Subunit alpha of PDH (PDHA1) contains the PDH active site [ 6 ]. The activity of PDHA1 can be regulated by acetylation. PDHA1 acetylation reduces PDH activity, and deacetylation enhances PDH activity [ 6, 7, 8, 9 ]. PDHA1 inactivation is believed to be involved in metabolic reprogramming and lactate overproduction in tumor [ 6 ].

    PDHA1 hyperacetylation-mediated lactate overproduction promotes se…

    nature.com
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  4. Semantic Scholar
    https://www.semanticscholar.org/paper/Deciphering-PDH1's...

    Deciphering PDH1's role in mung bean domestication: a ...

  5. New Phytologist
    https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.19150

    Parallel selection of loss‐of‐function alleles of Pdh1 ...

  6. National Center for Biotechnology Information
    https://ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Term=...

    PDH1 prephenate dehydrogenase 1 [ Glycine max (soybean) ]

  7. Nature
    https://www.nature.com/articles/s41419-023-06249-2

    Pyruvate dehydrogenase kinase 1 protects against neuronal ...

  8. Europe PMC
    https://europepmc.org/article/MED/37501344

    Parallel selection of loss-of-function alleles of Pdh1 ...

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10362039

    PDHA1 hyperacetylation-mediated lactate overproduction ...

  10. Springer
    https://link.springer.com/referenceworkentry/10.1007/978...

    Pyruvate Dehydrogenase E1-Alpha Deficiency (PDHAD)

  11. Nature
    https://www.nature.com/articles/s41467-023-40738-4

    Pyruvate dehydrogenase operates as an intramolecular ...

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