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  1. PubMed
    https://pubmed.ncbi.nlm.nih.gov/26657143

    Clearance of senescent cells by ABT263 rejuvenates aged …

    pubmed.ncbi.nlm.nih.gov の検索結果のみを表示
  2. Nature
    https://www.nature.com/articles/nm.4010

    Clearance of senescent cells by ABT263 rejuvenates aged ...

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    Treatment with the BCL-2/BCL-xL inhibitor senolytic drug …
    link.springer.com
    Effects and Related Mechanisms of the Senolytic Agent …
    pubmed.ncbi.nlm.nih.gov
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  3. 他の人はこちらも質問
    How does ABT263 affect senolytic activity?
    ABT‐263 exerts its senolytic activity in senescent tumor cells by inhibiting BCL‐X L 's interaction with BAX Members of the BCL‐2 family regulate the survival of different types of malignant cells and have also been shown to mediate the resistance of senescent cells to cell death [ 38, 39 ].

    Clearance of therapy‐induced senescent tumor cells by the

    ncbi.nlm.nih.gov
    Is ABT263 a senolytic drug?
    To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. We show that ABT263 selectively kills SCs in culture in a cell type- and species-independent manner by inducing apoptosis.

    Clearance of senescent cells by ABT263 rejuvenates aged ... - PubMed

    pubmed.ncbi.nlm.nih.gov
    How does Bcl-xL-Bax interact with senolytic ABT-263?
    Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-XL -BAX interaction Tumor cells undergo senescence in response to both conventional and targeted cancer therapies.

    Clearance of therapy-induced senescent tumor cells by the

    pubmed.ncbi.nlm.nih.gov
    Does the senolytic agent ABT-263 affect the survival of irradiated A549 and ca9-22 cancer?
    Here, the effects of the senolytic agent ABT-263 on the survival of irradiated A549 and Ca9-22 cancer cells were investigated. ABT-263 was added to the culture medium after irradiation. SA-β-gal activity and cell size, which are hallmarks of cell senescence, were evaluated using a flow cytometer.

    Effects and Related Mechanisms of the Senolytic Agent ABT-263 on the …

    pubmed.ncbi.nlm.nih.gov
    フィードバック
  4. Nature
    https://www.nature.com/articles/s41467-020-15838-0

    Using proteolysis-targeting chimera technology to reduce ...

    タグ:
    Publish Year:2020
    Navitoclax Platelet
    Proteolysis Targeting Chimera
  5. Nature
    https://www.nature.com/articles/s43587-023-00415-z

    Discovering small-molecule senolytics with deep neural networks

    タグ:
    Felix Wong
    Nature
  6. PubMed
    https://pubmed.ncbi.nlm.nih.gov/32652830

    Clearance of therapy-induced senescent tumor cells by the ...

    タグ:
    Publish Year:2020
    ABT-263
    Clearance of Senescent Cells
  8. J-GLOBAL 科学技術総合リンクセンター
    https://jglobal.jst.go.jp/detail?JGLOBAL_ID=...

    幹細胞:ABT263による老化細胞の除去はマウスの老化した造血幹 ...

  9. Springer
    https://link.springer.com/article/10.1007/s11357-021-00440-z

    Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ...

    タグ:
    Publish Year:2021
    B-cell CLL/lymphoma 2
  10. Stem Cell Research & Therapy
    https://stemcellres.biomedcentral.com/articles/10.1186/s...

    Clearance of senescent cells with ABT-263 improves ...

    タグ:
    ABT-263
    Clearance of Senescent Cells
    Stem Cells
    Stem Cell Research

  12. ABT 263 senolyticの画像

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