Landscape of immune cells in systematic lupus ...
WebDec 11, 2023 · Study design and single-cell transcriptional profiling of PBMCs from HCs and patients with SLE, with or without concurrent EBV infection. (A) Study design schematic.(B) Cellular populations identified from two SLE-EBV+, four SLE-EBV– and two HCs, forming eight clusters with their respective labels. ...
Molecular pathways identified from single nucleotide ...
WebApr 1, 2023 · Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry Systemic lupus ...
Genetics of SLE: mechanistic insights from monogenic ...
WebJul 12, 2023 · This Review examines insights from genetic studies of systemic lupus erythematosus (SLE), including observations from reports of monogenic SLE, as well as the role of common and rare variants. The ...
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Restoration of aberrant gene expression of monocytes in ...
WebApr 18, 2023 · Background Monocytes -key regulators of the innate immune response- are actively involved in the pathogenesis of systemic lupus erythematosus (SLE). We sought to identify novel compounds that might serve as monocyte-directed targeted therapies in SLE. Results We performed mRNA sequencing in monocytes from 15 patients with active SLE …
Systemic Lupus Erythematosus Patients with DNASE1L3 ...
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WebMar 31, 2023 · Cells 2023, 12, 1061 2 of 17 weight DNA fragments, and then into oligonucleosomal fragments; and finally, cfDNA fragments are cleared by DNASES, DNASE1 (for <150 bp fragments), and DNASE1L3 (for larger and
Cytokines in Systemic Lupus Erythematosus—Focus on TNF ...
WebSep 22, 2023 · Systemic lupus erythematosus (SLE) is an autoimmune disorder known for its complex pathogenesis, in which cytokines play an essential role. It seems that the modulation of these cytokines may impact disease progression, being considered potential biomarkers. Thus, TNF (tumor necrosis factor)-α and IL (interleukin)-17 are molecules of …
NR_103776.1 as a novel diagnostic biomarker for systemic ...
WebJun 27, 2023 · Background With the development of sequencing technologies, there is increasing evidence that long noncoding RNAs (lncRNAs) are involved in systemic lupus erythematosus (SLE). The level of NR_103776.1 expression in SLE and its clinical associations are still not well defined. Objective To identify differentially expressed …
Managing infections: systemic lupus erythematosus patients ...
WebJul 27, 2023 · Correspondence: Jamal Mikdashi, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, 10 South Pine Street, Suite 834, Baltimore, MD, 21201, USA, Tel +1 410 706 6474, Fax +1 410 7060231, Email jmikdash@som.umaryland.edu. Abstract: Infections remain one of the leading causes of …
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