Critical pediatric neurological illness associated with COVID-19 ...
WebSep 7, 2022 · The sequences displayed a novel K97E mutation in the spike protein. •. Only mutations from Japan, the United States, and Hong Kong showed a high correlation. •. This strain appeared in April 2022 (coincided with the Omicron outbreak in …
Omicron Mutation Linked to Neurological Complication in Kids
WebSep 27, 2023 · Moreover, the sequences had previously unidentified K97E mutation in the S protein that differed from other BA.2.3.7 lineage strains. Researchers say these severe neurological symptoms might be related to hyperimmune states triggered by the mutation.
Critical pediatric neurological illness associated with COVID-19 ...
WebNov 1, 2022 · The sequences displayed a novel K97E mutation in the spike protein. Only mutations from Japan, the United States, and Hong Kong showed a high correlation. This strain appeared in April 2022 (coincided with the Omicron outbreak in Taiwan).
Critical pediatric neurological illness associated with COVID-19 ...
WebHowever, the sequences had a K97E mutation in the S protein that differed from other BA.2.3.7 lineage strains, which was located at the S protein N-terminal domain. Conclusion: The new mutation in the S protein, which had not previously been observed but was discovered in this study, potentially explains the sudden increase in incidence of ...
News Scan for Sep 08, 2022 | CIDRAP
WebSep 8, 2022 · "The K97E mutation, which has not been observed in Taiwan previously, potentially explains the sudden increase in incidence of severe neurological symptoms in pediatric patients due to its possible effect on immune regulation," the researchers concluded. Sep 7 Int J Infect Dis study. Flu continues drop in Southern Hemisphere.
Epidemiology and analysis of SARS-CoV-2 Omicron subvariants …
WebOct 3, 2023 · The results revealed that BA.2.3.7, featuring K97E and G1251V in the spike protein compared with BA.2, emerged in March 2022 and persistently dominated between April 2022 and August 2022,...
WebThe sequences displayed a novel K97E mutation in the S protein. Only mutations from Japan, the USA, and the Hong Kong showed a high. correlation. This strain appeared in April 2022 (coincided...
Webwith 3 amino acid changes (ORF1a: L631F; S: K97E; and nucleocapsid: M322I) was circulating dominant-ly in Taiwan over the study period. Of note, the first BA.2.3.7 strain identified in the epidemic in Taiwan was collected on March 27, 2022, and since that time we detected several genomic changes affecting this Omicron lineage.
Encephalitis in kids might be caused by mutation in virus
WebSep 15, 2022 · The K97E mutation is believed to play a critical role in disrupting the immune system, causing systemic inflammatory response, cytokine storm and acute encephalitis, Department of Pediatrics attending physician Chang Chia-ning (張佳寧) said.
PURA Syndrome-causing mutations impair PUR-domain integrity …
WebFull text. Figures. Peer review. Abstract. Mutations in the human PURA gene cause the neuro-developmental PURA syndrome. In contrast to several other mono-genetic disorders, almost all reported mutations in this nucleic acid binding protein result in …
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