WebAug 28, 2023 · PFS Investigator Roberto Melcangi suspects the post-treatment variety springs from neuroendocrine disorder, rather than genital pathology. Aug. 28, 2023. Dear Friends: Finasteride use can, and does, lead to erectile dysfunction that can, and does, last indefinitely in a subset of patients. By this point in the epidemiology of PFS, few self ...