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  1. Nature
    https://www.nature.com/articles/s41401-023-01149-9

    Neuronal K+-Cl- cotransporter KCC2 as a promising drug …

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    Role of NKCC1 and KCC2 in Epilepsy: From Expression …
    pubmed.ncbi.nlm.nih.gov
    KCC2 is a hub protein that balances excitation and …
    sciencedirect.com
    KCC2 is required for the survival of mature neurons but …
    sciencedirect.com
    KCC2 Chloride Transport Contributes to the Termination …
    eneuro.org
    The K+/Cl- co-transporter KCC2 renders GABA …
    pubmed.ncbi.nlm.nih.gov
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  2. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016893

    The Expanding Therapeutic Potential of Neuronal KCC2

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    Molecular architecture of potassium chloride co-transporter …
    nature.com
    KCC2 membrane diffusion tunes neuronal chloride …
    pubmed.ncbi.nlm.nih.gov
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  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730145

    The Therapeutic Potential of Neuronal K-Cl Co …

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    The K+/Cl− co-transporter KCC2 renders GABA …
    nature.com
    The KCC2 Cotransporter and Human Epilepsy: Getting …
    pubmed.ncbi.nlm.nih.gov
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  4. Studies of CD-KCC2
    National Center for Biotechnology Information
    The Expanding Therapeutic Potential of Neuronal KCC2
    Dysfunctions in GABAergic inhibitory neural transmission occur in neuronal injuries and neurological disorders. The potassium–chloride cotransporter 2 (KCC2, SLC12A5) is a key modulator of inhibitory GABAergic inputs in healthy adult neurons, as its chloride
    Author: Bor Luen Tang
    Published: 2020/01
    Publication: Cells. 202…
    National Center for Biotechnology Information
    The Therapeutic Potential of Neuronal K-Cl Co-Transporter KCC2 in Huntington’s Disease and Its Comorbidities
    Intracellular chloride levels in the brain are regulated primarily through the opposing effects of two cation-chloride co-transporters (CCCs), namely K+-Cl− co-transporter-2 (KCC2) and Na+-K+-Cl− co-transporter-1 (NKCC1). These CCCs are differentially
    Author: Katie Andrews…
    Published: 2020/12
    Publication: Int J Mol …
    PubMed
    Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2
    KCC2, a neuronal-specific K-Cl cotransporter, plays a major role in maintaining intracellular Cl(-) concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses. The pharmacology
    Author: Eric Delpire
    Published: 2009/03/31
    Keywords: National In…
    PubMed
    Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability
    Introduction: Epilepsy is a common neurological disorder of neuronal hyperexcitability that begets recurrent and unprovoked seizures. The lack of a truly satisfactory pharmacotherapy for epilepsy highlights the clinical urgency for the discovery of new
    Author: Phan Q Duy
    Published: 2020/7
    Keywords: Epilepsy is …
    National Center for Biotechnology Information
    Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
    The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with several neurological conditions. By regulating intraneuronal chloride homeostasis, KCC2 strongly
    Author: Ingrid Chamm…
    Published: 2012
    Publication: Front Cel…
    ScienceDirect
    Chapter 8 - KCC2 is a hub protein that balances excitation and inhibition
    The K+-Cl− cotransporter KCC2 is an evolutionarily conserved neuron-specific cation-chloride cotransporter (CCC) that plays vital roles in both inhibitory and excitatory synaptic transmission. KCC2 is responsible for maintaining the chloride (Cl−)-gradient,
    Published: 2020/01/01
    Cited By: 0
    Keywords: KCC2; GA…
    PubMed
    KCC2, epileptiform synchronization, and epileptic disorders
    The K+-Cl- co-transporter KCC2 is a neuron-specific, Cl- extruder that uses K+ gradient for maintaining low intracellular [Cl-]. It is indeed well established that sustaining an outwardly-directed electrochemical Cl- gradient across the neuronal membrane
    Author: Graziella Di Cr…
    Published: 2018/3
    Keywords: Context-sp…
    National Center for Biotechnology Information
    Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability
    Epilepsy is the most common serious brain disorder worldwide that affects approximately one percent of the population [1]. The clinical hallmark of epilepsy is heightened propensity of the brain to generate recurrent and unprovoked seizures. Seizures
    Author: Phan Q. Duy, …
    Published: 2020/07
    DOI: 10.1080/1472822…
  5. Nature
    https://www.nature.com/articles/s41598-017-15739-1

    Molecular architecture of potassium chloride co …

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    Publish Year:2017
    Potassium
  6. Science | AAAS
    https://www.science.org/doi/10.1126/scisignal.ab…

    Targeting ischemia-induced KCC2 hypofunction rescues …

    WEBNov 9, 2021 · In a CD-1 mouse model of refractory ischemic neonatal seizures, treatment with the KCC2 functional enhancer CLP290 rescued phenobarbital efficacy, increased KCC2 abundance, and prevented the …

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    Publish Year:2021
    Seizures
  7. Nature
    https://www.nature.com/articles/s42003-021-017…

    The structural basis of function and regulation of neuronal ...

    WEBFeb 17, 2021 · Cation-chloride cotransporters (CCC) are central to the regulation of intracellular Cl − concentration and have key physiological roles in neuronal excitability, trans-epithelial salt and...

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    Publish Year:2021
    Cation-chloride Cotransporters
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  9. PubMed
    https://pubmed.ncbi.nlm.nih.gov/19279215

    Small-molecule screen identifies inhibitors of the …

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    Publish Year:2009
  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov/32336175

    Preclinical insights into therapeutic targeting of KCC2 for …

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    Publish Year:2020
    Kcc2 Epilepsy
    Kcc2 Benefits
  11. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10770335

    Neuronal K+-Cl- cotransporter KCC2 as a promising drug …

  12. Journal of Biological Chemistry
    https://www.jbc.org/article/S0021-9258(19)7340…

    The Neuron-specific K-Cl Cotransporter, KCC2 - Journal of …

    WEBThe neuron-specific K-Cl cotransporter (KCC2) is hypothesized to function as an active Cl − extrusion pathway important in postsynaptic inhibition mediated by ligand-gated anion channels, like γ-aminobutyric acid type …

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    Kcc2 Function
    Publish Year:1999

  13. Images of CD-KCC2

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