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    Fig. 5: The schematic illustration of P57 regulating body temperature. The natural product P57 crossed the blood-brain barrier and entered the brain, inhibiting PDXK enzyme activity, leading to the accumulation of PL, and eventually causing the mouse core body temperature to drop.
    In addition to thermoregulation, POA is also involved in regulating sleep and feeding behavior 28, 56, 60, 61. P57 is well-known for its prominent activity in appetite suppression with undefined mechanism 39, 40, so P57 may also target POA to regulate feeding behavior and sleep.
    Target identification of natural products is one of the main bottlenecks in drug development. Previous studies showed that P57 significantly suppressed appetite activity and decreased body weight 40, 52, 53, but the underlying mechanisms are unclear, which is the one of limiting factors for its clinical application 45, 52, 53.
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