- Cyto-plasmic STAT3 monomers dimerize when phosphorylated at tyrosine 705 (Y705) by Janus kinases (JAKs) associated with cytokine-stimulated receptors, and then translocate to the nucleus, where the homodimers activate target gene transcription.Author: Guanyi Huang, Hexin Yan, Shoudong Ye, Chang Tong, Qi-Long YingPublish Year: 2014DOI: 10.1002/stem.1609Published: 2014/05www.ncbi.nlm.nih.gov/pmc/articles/PMC4181708/
Polyclonal Antibody for studying STAT3 (Tyr705) phosphate. Cited in 1476 publications. Validated for WB, WB, IP, ChIP. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-Stat3 (Tyr705) Antibody (CST #9131) is ready to ship. See more
For western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, … See more
From sample preparation to detection, the reagents you need for your Western Blot are now in one convenient kit: #12957Western Blotting Application Solutions Kit NOTE: … See more
NOTE: Volumes are for 10 cm x 10 cm (100 cm2) of membrane; for different sized membranes, adjust volumes accordingly. See more
- A general protocol for sample preparation.
- 1. Treat cells by adding fresh media containing regulator for desired time. 2. Aspirate media from c… See more
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WebNov 9, 2023 · Abstract. The signal transducer and activator of transcription 3 (STAT3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (Y705) or …
WebDec 1, 2020 · A IHC analysis of lung cancer tissue array samples for IL6R, pY705-STAT3, LIFR, and pS727-STAT3. Both low-grade (stage IIA) and high-grade (stage IV) cancer …
- Author: Wei-Hsin Lin, Yi-Wen Chang, Min-Xiang Hong, Te-Cheng Hsu, Ko-Chuan Lee, Che Lin, Jia-Lin Lee
- Publish Year: 2021
WebAbstract. STAT3 can be transcriptionally activated by phosphorylation of its tyrosine 705 or serine 727 residue. In mouse embryonic stem cells (mESCs), leukemia inhibitory factor …
WebMar 14, 2022 · In a nude mouse tumorigenesis model, Stattic inhibited PC growth by antagonizing STAT3 Y705 phosphorylation. Interleukin-6 used as a molecule agonist to …
WebApr 15, 2020 · pSTAT3 Y705 is a prognostic biomarker identified from time-series gene expression profiles of a chemically induced mouse model of hepatocellular carcinoma - …
WebNov 5, 2019 · p-Stat3 Y705 immunohistochemical expression influences survival in glioblastoma. We found a statistically significant survival difference between subjects …
WebNov 5, 2019 · 4944/4/08.03/2016/Iuliu Hatieganu University of Medicine and Pharmacy. The results obtained show that the immunohistochemical expression of pY705-Stat3 …
WebApr 15, 2020 · pSTAT3 Y705 is a prognostic biomarker identified from time-series gene expression profiles of a chemically induced mouse model of hepatocellular carcinoma. …
WebNov 5, 2019 · On multivariate analyses with the COX proportional hazards regression model including pY705-Stat3 expression, age and relapse status, pY705-Stat3 status was an …
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