Tracking C–H activation with orbital resolution | Science
ウェブ2023年6月1日 · Abstract. Transition metal reactivity toward carbon–hydrogen (C–H) bonds hinges on the interplay of electron donation and withdrawal at the metal center. Manipulating this reactivity in a controlled way is difficult because the hypothesized metal-alkane charge-transfer interactions are challenging to access experimentally.
Chelation-Assisted Iron-Catalyzed C–H Activations: Scope ...
ウェブ2023年12月20日 · Jump To. The major challenge in C–H activation lies in the wealth of C–H bonds with comparable bond dissociation energies. While the choice of catalyst and ligand governs the C–H activation efficiency, site-selectivity control can be achieved by chelation assistance, bringing the metal near the target C–H bond.
Kinetic and thermodynamic control of C(sp2)–H activation ...
ウェブ8 Dec 2023. C–H functionalization has enhanced chemical synthesis by providing a direct method for the activation of otherwise inert bonds, providing a straightforward route to molecules with applications as pharmaceuticals, agrochemicals, and aromatics relevant to materials science.
Mechanistic Insights into the Origins of Selectivity in a Cu ...
ウェブ2024年2月21日 · The catalytic transformation of C–H to C–N bonds offers rapid access to fine chemicals and high-performance materials, but achieving high selectivity from undirected aminations of unactivated C (sp 3 )–H bonds remains an outstanding challenge. We report the origins of the reactivity and selectivity of a Cu-catalyzed C–H …
Hydrogen-bond-acceptor ligands enable distal C(sp3)–H ...
ウェブ2023年9月6日 · Jin-Quan Yu. Nature 622 , 80–86 ( 2023) Cite this article. 19k Accesses. 7 Citations. 82 Altmetric. Metrics. The functionalization of C–H bonds in organic molecules is one of the most direct...
Direct Heterocycle C–H Alkenylation via Dual Catalysis Using ...
ウェブ2024年1月11日 · Direct Heterocycle C–H Alkenylation via Dual Catalysis Using a Palladacycle Precatalyst: Multifactor Optimization and Scope Exploration Enabled by High-Throughput Experimentation | The Journal of Organic Chemistry. RETURN TO ARTICLES ASAP PREV Article NEXT.
Accessing metal-specific orbital interactions in C–H activation ...
ウェブ2024年1月9日 · Photochemically prepared transition-metal complexes are known to be effective at cleaving the strong C–H bonds of organic molecules in room temperature solutions. There is also ample theoretical evidence that the two-way, metal to ligand (MLCT) and ligand to metal (LMCT), charge-transfer between an incoming alkane C–H …
Homolytic C−H Bond Activation by Phosphine−Quinone ...
ウェブ2023年10月13日 · Herein, we present the formation of transient radical ion pairs (RIPs) by single-electron transfer (SET) in phosphine−quinone systems and explore their potential for the activation of C−H bonds. PMes 3 (Mes=2,4,6-Me 3 C 6 H 2) reacts with DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) with formation of the P−O bonded zwitterionic …
Reversible C–H sampling for direct functional group translocation
ウェブ2023年12月21日 · While this long-established approach demonstrates high reactivity in cleaving various C–H bonds and is compatible with a wide range of functional groups, achieving precise site-selectivity control can be challenging, particularly with complex molecules that contain similar and unactivated C–H bonds.
Organocatalytic olefin C–H functionalization for ...
ウェブ2024年1月17日 · Classical alkene C–H functionalization approaches including the Heck reaction, Morita–Baylis–Hillman reaction and electrophilic or radical addition generally occur by an addition/elimination ...
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