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  1. Mechanisms of synergistic suppression of ALK-positive lung

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    Our study thus identifies SHP-1 as a druggable target for the treatment of IPF, and suggests that the SHP-1 agonist may be developed as an anti-pulmonary fibrosis medication that both suppresses inflammation and restrains fibroblast-to-myofibroblast transition.
    Our data showed that SHP-1 mRNA ( P = 0.0028; Figure 1 a) and protein ( P = 0.0012; Figure 1 b) levels were significantly increased in the kidney cortex of patients with diabetes by 1.4-fold and 3.5-fold, respectively, as compared with those without diabetes.
    Our report indicates that pharmacological activation of SHP-1 ameliorates pulmonary fibrosis via suppression of CSF1R signaling in macrophages, reduction of pathogenic macrophages, and the inhibition of fibroblast-to-myofibroblast transition.
    Our study demonstrated that the expression of podocin and the phosphorylation of nephrin are reduced in diabetes and prevented by the deletion of SHP-1. Moreover, podocin binds and regulates the transient receptor potential channel 6, which is also critically involved in proteinuric kidney disease.
  3. Aberrant non-canonical NF-ฮบB signalling reprograms the ... - Nature

  4. Minimum supported extension versions for ePolicy Orchestrator

  5. Deletion of protein tyrosine phosphatase SHP-1 restores โ€ฆ

  6. KB1SHP - Callsign Lookup by QRZ Ham Radio

  7. Pre- and Post-Transcriptional Control of HBV Gene Expression: The โ€ฆ

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