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  1. T2 Hyperintensity – Radiology In Plain English

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    Our characterization of PD-1 TMD dimerization may help inform evolving strategies for developing both agonists and antagonists. In contrast to other coreceptors like CD28, ICOS, and CTLA-4 that are constitutive dimers established by disulfide bonds, PD-1 dimerization is driven by noncovalent association of its TMD.
    In contrast to other coreceptors like CD28, ICOS, and CTLA-4 that are constitutive dimers established by disulfide bonds, PD-1 dimerization is driven by noncovalent association of its TMD. The more dynamic dimerization of the PD-1 axis described here affords an additional mode of regulation.
    No eLetters have been published for this article yet. Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolera...
    B6 mice with B16 melanoma tumors were adoptively transferred with PD-1 −/− OT1 cells rescued with high and low dimerization PD-1 mutants to measure the functional impact of PD-1 dimerization on antitumor immunity and cytotoxic T cell function.
  3. 5 Coping Strategies For Living With Multiple Personality Disorder