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  1. Structures revealing mechanisms of resistance and collateral ...

  2. 他の人はこちらも質問
    The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous drug target because its inhibition kills P. falciparum in multiple stages of its life cycle and synergizes with artemisinins.
    Many efforts have been poured into the development of oral Pf20S-selective inhibitors, with some success. Peptide boronate MPI-13 is optimized to be orally bioavailable but is only modestly selective in targeting Pf20S over human constitutive proteasome and non-selective in being equally potent against human immunoproteasome 17.
    At present, however, Pf20S inhibitors that spare both human constitutive (c-20S) and immuno-proteasomes (i-20S) are not orally bioavailable.
    Thus, Pf20S inhibitors hold the potential to reduce the emergence of resistance to and spread of ART resistance. Many efforts have been poured into the development of oral Pf20S-selective inhibitors, with some success.
  3. Novel inhibitors of malaria proteasome - MESA

  4. 8UD9 - RCSB PDB

  5. 3M プライバシーフィルター 覗き見防止 セキュリティ 個人情報 ...

  6. Selective Plasmodium proteasome inhibitors as novel multi ...

  7. PF20S Mag-Mate | Octopart Electronic Components

  8. Cell Press: STAR Protocols

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