Clinical manifestations and diagnosis of systemic lupus ... - UpToDate
WebJun 16, 2023 · Definite SLE — After excluding alternative diagnoses, we diagnose SLE in the patient who fulfills the 1997 ACR criteria, the 2012 SLICC criteria (), or the 2019 EULAR/ACR criteria ().As previously mentioned, the ACR criteria require that a patient satisfy at least 4 of 11 criteria. The SLICC criteria require either that a patient satisfy at …
Systemic Lupus Erythematosus - StatPearls - NCBI Bookshelf
WebAug 4, 2023 · HHS. USA.gov. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement.
Systemic lupus erythematosus (renal manifestations)
WebFeb 8, 2024 · Renal manifestations of systemic lupus erythematosus include several conditions secondary to systemic lupus erythematosus (SLE) effecting the kidneys. While lupus nephritis drives kidney damage in many patients other entities considered by some but not all separate, such as lupus podocytopathy, are also associated with SLE 1.
Precision medicine in systemic lupus erythematosus - Nature
WebApr 11, 2023 · Systemic lupus erythematosus (SLE) is an autoimmune disease that has diverse clinical manifestations, ranging from restricted cutaneous involvement to life-threatening systemic organ...
Biological Agents Effectively Treat Systemic Lupus Erythematosus
WebNov 20, 2023 · A review of high-quality studies demonstrated that multiple biologic agents significantly improved outcomes among patients with systemic lupus erythematosus (SLE), according to study results published in BMC Rheumatology. Multiple biological agents have recently emerged as potential novel treatments for SLE.
Regulatory T cells expressing CD19-targeted chimeric antigen
WebMar 27, 2024 · In summary, Fox19CAR-Tregs can break the vicious cycle leading to autoimmunity and persistent tissue damage, representing an efficacious and safe strategy allowing restoration of homeostasis in...
Distinct transcriptomes and autocrine cytokines underpin ... - Nature
WebMar 1, 2024 · Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates...
Physician global assessment for type 2 manifestations of systemic …
WebFeb 2, 2024 · Bookmark this article. Systemic lupus erythematosus (SLE) manifestations are categorized as type 1 (classic signs and inflammatory symptoms) and type 2 (including symptoms of fatigue, depression, widespread pain, and brain fog). The type 2 manifestations, substantially impacting the quality of life, are reported more frequently by …
Current treatment of systemic lupus erythematosus: a clinician's ...
WebMay 12, 2023 · Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Its variable course makes it difficult to standardize patient treatment. This article aims at a literature review on available drugs for treating SLE and on drugs that have shown therapeutic effects in this disease.
Anifrolumab May Help Prevent Organ Damage in Patients With …
WebDec 13, 2023 · Anifrolumab exhibited a high retention rate, effectively improved disease activity, and reduced glucocorticoid (GC) doses among patients with systemic lupus erythematosus (SLE), including those who experienced minor flares after achieving low disease activity, according study results published in Rheumatology.
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