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PubMed
https://pubmed.ncbi.nlm.nih.gov/18451170
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
WEBMay 1, 2008 · In human tumor cells, ABT-263 induces Bax translocation, cytochrome c release, and subsequent apoptosis. Oral administration of ABT-263 alone induces …
- Author: Christin Tse, Alexander R. Shoemaker, Jessica Adickes, Mark G. Anderson, Jun Chen, Sha Jin, Eric F. ...
- Publish Year: 2008
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An inhibitor of Bcl-2 family proteins induces regression of …
nature.com
Inhibition of Bcl-2/xl With ABT-263 Selectively Kills ... - PubMed
pubmed.ncbi.nlm.nih.gov
Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven ... - …
nature.com
An Ongoing Phase 1 Study of ABT-263; Pharmacokinetics, …
ashpublications.org
ABT-263 Reduces Hypertrophic Scars by Targeting …
pubmed.ncbi.nlm.nih.gov
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Wikipedia
https://en.wikipedia.org/wiki/Navitoclax
Navitoclax - Wikipedia
Overview
Mechanism of action
Effects against senescent cells
Clinical trials
Antisclerotic
Navitoclax (previously ABT-263) is an experimental orally active anti-cancer drug, which is a Bcl-2 inhibitor similar in action to obatoclax.
Wikipedia · Text under CC-BY-SA license
- CAS Number: .mw-parser-output .plainlist …
- Chemical formula: C₄₇H₅₅ClF₃N₅O₆S₃
- ChEBI: CHEBI:131174
- Molar mass: 974.61 g·mol−1
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Navitoclax Shows Early Signs of Clinical Benefit in …
onclive.com
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in ... - …
pubmed.ncbi.nlm.nih.gov
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What is ABT-263 (navitoclax)?
ABT-263 (Navitoclax), a novel BH3 mimetic and orally bioavailable Bcl-2 family inhibitor with high affinity for Bcl-xL, Bcl-2 and Bcl-w has entered clinical trials for cancer treatment. But the anticancer mechanisms of ABT-263 have not been fully elucidated.
ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in ... - …
nature.com
Is ABT-263 a bioavailable Bcl-2 family inhibitor?
Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008;68:3421–8.
Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven ... - Nature
nature.com
Is ABT-263 a chemotherapeutic?
In summary, we describe here the properties of ABT-263, an orally bioavailable Bcl-2 family protein inhibitor that not only exhibits robust single-agent activity but also significantly enhances the antitumor activity of common chemotherapeutics.
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
aacrjournals.org
Is ABT-263 a melanoma inhibitor?
Tse, C. et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68, 3421–3428 (2008). Natale, C. A. et al. Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade. Elife 7, e31770 (2018).
Targeting anti-apoptotic pathways eliminates senescent melanocytes …
nature.com
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AASJホームページ
https://aasj.jp/news/watch/15730
5月21日慢性腎臓病（CKD）と細胞老化（5月19日号 Science ...
WEBMay 21, 2021 · ABT-263処理により、老化マーカーを発現する細胞が減少させるとともに、急性腎障害による繊維化をおさえ、さらに尿細管細胞の再生増殖が高まる。すなわ …
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老化細胞を選択的に除去するGLS1阻害剤が加齢現象 ...
amed.go.jp
幹細胞:ABT263による老化細胞の除去はマウスの老化し ...
jglobal.jst.go.jp
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Nature
https://www.nature.com/articles/s41419-021-03971-7
Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven ...
WEBJul 13, 2021 · Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy | Cell Death & Disease. Article. Open access. Published: 13 July …
- Author: Violetta Ritter, Franziska Krautter, Diana Klein, Verena Jendrossek, Justine Rudner
- Publish Year: 2021
(セレックバイオテック株式会社)Selleck.co.jp
https://www.selleck.co.jp/products/ABT-263.html
Navitoclax (ABT-263) | ≥99%(HPLC) | Selleck | Bcl-2 阻害剤
WEBナビトクラックス (Navitoclax (ABT-263)) は Bcl-xL, Bcl-2 and Bcl-w の強力な阻害剤であり、阻害定数は cell-free assay において Ki ≦ 0.5 nM, 1 nM および 1nM です。一方 …
American Association for Cancer Research
https://aacrjournals.org/cancerres/article/68/9/3421/...
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
WEBMay 1, 2008 · ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor | Cancer Research | American Association for Cancer Research. Experimental Therapeutics, …
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Navitoclax (ABT-263) | Bcl-2 抑制剂 | 现货供应 | 美国品牌 | 免费采购电话400-668-6834
adooq.cn
ABT-263 | Bcl-2 inhibitor | Buy Navitoclax from Supplier AdooQ®
yeasen.com
Bcl-2蛋白家族抑制剂|Navitoclax(ABT-263,ABT 263)|CAS 923564-51-6
cellagentech.com
ABT-263 (Navitoclax) | Bcl-2 family inhibitor - Cellagen Technology
apexbt.com
ABT-263 (Navitoclax) | Potent Bcl-2 family inhibitor, inhibits Bcl-2 ...
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