HSPA9 reduction exacerbates symptoms and cell death in ...
WEBMar 11, 2024 · In a dextran sodium sulfate-induced colitis mouse model, the downregulated HSPA9 exacerbates colitis symptoms, including increased immune cell infiltration, elevated proinflammatory cytokines,...
HSPA9/mortalin inhibition disrupts erythroid maturation ...
WEBMar 19, 2024 · HSPA9 /mortalin inhibition disrupts erythroid maturation through a TP53 -dependent mechanism in human CD34+ hematopoietic progenitor cells. Christopher Butler, 1 Morgan Dunmire, 1 Jaebok Choi, 2 Gabor Szalai, 3 Anissa Johnson, 3 Wei Lei, 4 Xin Chen, 5 Liang Liu, 6 Wei Li, 7 Matthew J. Walter, 2 and Tuoen Liu 1,⁎,a.
Abstract 248: HSPA9/mortalin regulates erythroid maturation ...
WEBMar 22, 2024 · Abstract 248: HSPA9/mortalin regulates erythroid maturation through a TP53-dependent mechanism in human CD34+ hematopoietic progenitor cells | Cancer Research | American Association for Cancer Research. Volume 84, Issue 6_Supplement. 15 March 2024.
Single-cell transcriptional profiling of hearts during cardiac ...
WEBMay 23, 2023 · Therefore, abnormal regulation of Mfn1 and Hspa9 might have detrimental effects on the normal function of the heart and potentially induce cardiac hypertrophy. Genes highly enriched in CM2 and...
Enhanced primary ciliogenesis via mitochondrial oxidative ...
WEBMay 11, 2023 · Here, we showed that the depletion of heat shock protein family A member 9 (HSPA9)/mortalin stimulates primary ciliogenesis in SH-SY5Y cells. The downregulation of HSPA9 enhances mitochondrial stress by increasing mitochondrial fragmentation and mitochondrial reactive oxygen species (mtROS) generation.
Human HSP70-escort protein 1 (hHep1) interacts with ...
WEBNov 25, 2023 · Human Hsp70-escort protein 1 (hHep1) is a cochaperone that assists in the function and stability of mitochondrial HSPA9. Similar to HSPA9, hHep1 is located outside the mitochondria and can interact with liposomes. In this study, we further investigated the structural and thermodynamic behavior of interactions between hHep1 and ...
Hspa9 heat shock protein 9 [ Mus musculus (house mouse) ]
WEBJan 25, 2024 · Hspa9 provided by MGI. Official Full Name. heat shock protein 9 provided by MGI. Primary source. MGI:MGI:96245. See related. Ensembl:ENSMUSG00000024359 AllianceGenome:MGI:96245. Gene type. protein coding. RefSeq status. VALIDATED. Organism. Mus musculus. Lineage.
[PDF] HSPA9 reduction exacerbates symptoms and cell ...
WEBMar 11, 2024 · The finding that the reduction in HSPA9 significantly affected the superoxide dismutase 1 levels and contributed to cellular death enhances the understanding of the intricate mechanisms underlying colitis and contribute to the development of novel therapeutic approaches for this challenging condition. Expand. View on PubMed. …
Europe PMC
WEBSep 7, 2023 · Meanwhile, the expression of Hspa9 and Hspe1 was still significantly increased upon TM treatment, even in Atf4−/− MEFs rescued with the empty control vector (Supplementary Fig. S5b ), confirming the involvement of other transcription factors (e.g., ATF6 and XBP1s) in ER stress response 44, 45, 63.
A cytosolic surveillance mechanism activates the ...
WEBJun 7, 2023 · Treatment with the mitochondrial HSP90 inhibitor gamitrinib-triphenylphosphonium (GTPP) 1 causes MMS and significantly induced the UPR mt genes within 2–3 h but not general mitochondrial genes...
Skip to content